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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
1.52
Human Site:
S1393
Identified Species:
2.38
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1393
G
S
V
P
L
S
S
S
P
P
A
T
H
F
P
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
P1440
P
G
K
S
K
A
T
P
E
K
S
L
H
D
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
P1426
P
G
K
S
K
A
T
P
E
K
S
L
H
D
K
Dog
Lupus familis
XP_537646
1532
174610
P1394
K
D
S
V
P
L
S
P
G
S
T
A
D
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
P1389
K
D
S
V
P
A
S
P
G
V
P
A
A
D
F
Rat
Rattus norvegicus
P41516
1526
173202
G1389
D
S
V
P
A
S
P
G
A
S
A
A
D
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
I1423
Q
T
A
K
A
M
E
I
Q
S
S
D
T
S
D
Chicken
Gallus gallus
O42130
1553
174974
A1415
P
P
V
S
V
P
R
A
Q
A
V
P
K
K
P
Frog
Xenopus laevis
NP_001082502
1579
178601
A1408
N
A
P
P
K
N
K
A
V
P
D
I
E
I
D
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1402
K
A
E
K
P
E
A
S
S
K
S
S
S
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
V1309
S
P
K
A
K
K
A
V
V
K
K
E
P
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1378
K
P
K
P
R
T
G
K
G
A
A
K
A
E
V
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
P1310
D
K
P
A
G
A
K
P
K
T
K
T
A
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
K1327
S
K
T
A
E
T
S
K
A
I
A
V
D
D
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
N1291
G
E
L
S
K
I
S
N
K
F
K
K
I
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
6.6
6.6
13.3
N.A.
6.6
40
N.A.
0
13.3
13.3
6.6
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
26.6
26.6
13.3
N.A.
13.3
40
N.A.
13.3
26.6
33.3
33.3
N.A.
6.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
7
20
14
27
14
14
14
14
27
20
20
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
14
0
0
0
0
0
0
0
0
7
7
20
27
20
% D
% Glu:
0
7
7
0
7
7
7
0
14
0
0
7
7
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
14
7
% F
% Gly:
14
14
0
0
7
0
7
7
20
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
20
7
0
% H
% Ile:
0
0
0
0
0
7
0
7
0
7
0
7
7
7
0
% I
% Lys:
27
14
27
14
34
7
14
14
14
27
20
14
7
7
20
% K
% Leu:
0
0
7
0
7
7
0
0
0
0
0
14
0
0
7
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% N
% Pro:
20
20
14
27
20
7
7
34
7
14
7
7
7
7
20
% P
% Gln:
7
0
0
0
0
0
0
0
14
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
14
14
14
27
0
14
34
14
7
20
27
7
7
14
7
% S
% Thr:
0
7
7
0
0
14
14
0
0
7
7
14
7
0
7
% T
% Val:
0
0
20
14
7
0
0
7
14
7
7
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _